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Although beta-blockers are known to reduce the sensitivity of exercise and dobutamine sestamibi SPECT imaging for the detection of coronary artery disease, little is known about their effects on vasodilator stress scintigraphy. Thus, Taillefer and colleagues studied 21 patients with catheter proven coronary artery disease during 3 different treatments on different days assigned in a random fashion.
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A United Kingdom survey of sudden arrhythmic death syndrome in 32 victims aged 4-64 with normal hearts at autopsy and a negative toxicologic screening test evaluated first-degree relatives of these victims.
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In this paper, Oral and colleagues compared 2 current ablation techniques in patients with paroxysmal atrial fibrillation.
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This widely publicized small trial has catapulted the mutant form of ApoA-1 Milano into the limelight. Many investigators have been working with this interesting lipoprotein since it was discovered in the 1980s that 38 carriers from a small village in Northern Italy have very low HDL levels but very little vascular disease.
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What characteristics of a neuropathy make Sjögren syndrome the likely diagnosis?
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In an entirely novel observation, Walz and associates describe a cellular prion protein variant associated with hippocampal sclerosis that seems to be partially predictive of seizure-free outcome in patients undergoing surgery for medically refractory mesial temporal lobe epilepsy.
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In this epidemiologic analysis of 22,312 individuals living in Norway, a total of 87 reported having developed multiple sclerosis. The risk of developing multiple sclerosis was significantly higher among smokers than among never-smokers.
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Economy class syndrome (ECS) refers to venous thromboembolic episodes among airline passengers who have remained immobile for long periods in cramped seating that impairs their circulation. Economy class passengers with little leg space are more likely to suffer such events than passengers in roomy first-class seats.
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Its a rare occurrence, but each year some institutions are subjected to a for-cause audit by the Office for Human Research Protections (OHRP). Such audits often turn up documentation problems and review process problems with the IRB, but occasionally they also highlight very serious problems relating to the clinical trials management, such as failure to provide adequate informed consent or failure to seek an IRB review, according to OHRP officials.
